Over the years various methods are developed to enhance the drug solubility, liquisolid technique is one of the promising technique. The new fundamental mathematical model introduced by S. Spireas and M. Bolton, 1999; which helps to formulate the liquisolid systems. Liquisolid systems are acceptably flowing and compressible powdered forms of liquid medications. According to the concept of liquisolid systems, liquid lipophilic drugs, or water-insoluble solid drugs dissolved in suitable non-volatile solvents, may be converted into free-flowing and readily compressible powders by a simple admixture with selected powder excipients referred to as the carrier and coating materials. Various grades of Microcrystalline or amorphous cellulose may be used as carrier, whereas very fine particle size Silica powders may be used as coating materials. This review covers the detail aspects of Liquisolid formulation technique for solubility enhancement of poorly soluble drugs. Improved drug release profiles are exhibited by such formulations for poorly soluble drugs.
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